Abstract

Evaluation of immunity-enhancing effects of Melaleuca Alternifolia concentrate ( MAC) in healthy subjects

Author(s): Ramrao Kendre, Ankush Kendre

Background: Melaleuca Alternifolia concentrate (MAC) is an essential oil extracted from a native Australian Plant Melaleuca Alternifolia. M. Alternifolia has anti-inflammatory, antimicrobial properties and antioxidant properties Aim: To evaluate the immunity-enhancing effects of 2 doses of MAC (150mg and 300mg) and compare it with a placebo and to evaluate and compare the safety of MAC versus placebo.

Methodology: This study was a randomized, double-blind, placebo-controlled study that enrolled male or female healthy subjects ≥ 40 years of age. 120 subjects were randomized in a 1:1:1 manner to either of the three treatment groups namely MAC 150mg od, MAC 300mg od or placebo 1 od. The primary efficacy end points were CD4 T lymphocyte count, CD8 T lymphocyte count, CD 19-B lymphocyte count and NK cells.

Results: After 4 weeks of daily administration of 150mg per day or 300mg per day of MAC, the CD4 and CD8 levels increased till week 4. The levels of NK increased every week as compared to baseline Conclusion: Melaleuca Alternifolia Concentrate (MAC) has immunostimulant effects. MAC stimulates T cells, B cells and upregulates NAK. MAC can have a vital role to play in maintaining good health by improving immunity