Abstract

Determinants of Multidrug Resistance Tuberculosis: Systemic Review and Meta-analysis

Author(s): Kaleab Tesfaye Tegegne, Andualem Zenebe, Abiyu Ayalew Assefa, Mekibib Kassa Tessema, Eleni Tesfaye Tegegne, Alelign Tadele Abebe, Berhanu Bifato , Muse Rike

Objective: The aim of this systemic review and meta-analysis was to determine demographic, behavioral and clinical risk factors for multiple drug-resistant 19 studies were included in the systemic review and meta-analysis.

Materials and Methods: Search engines; PubMed/Medline, Web of Science, Scopus and Google scholar were used to search related literatures on MDR TB and selected determinates of MDRTB. All data were independently extracted. We used a random-effects model according to the DerSimonian and Laird method.

Results: The risk of having MDR-TB in patients who have informal education was 0.67 times lower than that of patients who have formal education (RR=0.67; 95% CI, 0.46 to 0.96). The risk of having MDR-TB in patients who have Diabetes Mellitus was 1.33 times higher than that of patients who have no Diabetes Mellitus (RR of 1.33 and 95% CI, 1.01 to 1.77)

Conclusion: This systemic review and meta-analysis indicated that the risk of having MDR-TB in patients who have informal education was 0.67 times lower than that of patients who have formal education and the risk of having MDR-TB in patients who have Diabetes Mellitus was 1.33 times higher than that of patients who have no Diabetes Mellitus. Our review did not show the presence of association between MDR TB and other selected variables gender, smoking and alcohol. We recommend interested researchers on MDR TB to do further research on patient’s educational level as a risk factor for MDR-TB in order to explain the variation in MDR TB among patients with formal education and patients with informal education